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Crazy 8 Initiative Award Program

Grants to USA, Canada, and International Faculty
Doctors to Address Challenges in Pediatric Cancer Research

Agency Type:

Foundation / Corporation

Funding Source:

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Alex’s Lemonade Stand Foundation (ALSF)

LOI Date:


Deadline Date:

01/20/20 11:59 PM


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Grants to USA, Canada, and International Faculty Doctors at academic institutions to tackle specific challenges in pediatric cancer research. A letter of inquiry is required prior to submission of a full application. Funding is intended for research into innovative and thorough approaches that address the most difficult issues in pediatric cancer research.

The Crazy 8 Initiative creates a new funding pillar for ALSF, allowing the foundation to tackle specific challenges in pediatric cancer research that require substantial support for collaborative teams. The Crazy 8 Initiative kicked off in 2018 with a meeting that brought together more than 90 top scientists from around the world to contribute their expertise in eight key pediatric oncology disciplines:

1. Embryonal brain cancers
2. High-grade gliomas
3. Fusion positive sarcomas
4. Fusion negative sarcomas
5. Leukemias
6. Neuroblastoma
7. Big data
8. Catalyzing clinical trials

The group identified four cross-cutting research themes that form the basis of this RFA, with the overarching goal of making a major impact on the field of childhood cancer:

1. Developmental Origins of Pediatric Cancers
2. Drugging Currently Undruggable Pediatric Cancer Drivers
3. Developing Novel Immunotherapies
4. Discovery and Development of Novel Pediatric Cancer Drug Targets

The Crazy 8 Initiative Award will fund research into innovative and rigorous approaches that directly address the most intractable issues in pediatric cancer research today. This award is designed to coalesce cross-disciplinary cores of scientists working collaboratively in order to accelerate the pace of new cure discovery. The proposal should address a topic that is responsive to at least one of the four pediatric cancer research themes listed above. It is expected that successful applications will address one or more of the eight disciplines that formed the basis of the Crazy 8 initiative

Investigations may involve the exploration of a novel scientific hypothesis or the development of new model systems, tools or technologies that have the potential for significant impact on the field of childhood cancer. Collaboration and data sharing are a priority for this research program. The Foundation expects successful applications to propose multidisciplinary teams with a very clear plan for collaboration that would empower the study of big ideas that would not be easily addressable otherwise. Childhood cancer research applicants are encouraged to bring new, necessary expertise into the field. The awards will be judged on scientific soundness, significance and the potential for impact on improving the lives of children with cancer.

GrantWatch ID#:

GrantWatch ID#: 186473

Estimated Total Program Funding:


Estimated Size of Grant:

Depending on the type of project and the size of the team, the requested budget should be in the range of $1-5 million USD over 4 years.

ALSF will pay up to 10% in indirect costs; if the applicant elects to request indirect costs, the budget may not exceed the range of $1-5 million USD.

In addition to the full requested budget, applicants may elect to use the ALSF Childhood Cancer Data Lab (CCDL) for single-cell and/or bulk gene expression analysis. The CCDL is also available for consultations regarding the management and sharing of your research data which is a required element of this award (see Resource & Data Sharing). The use of the CCDL is not required and is meant to serve as a benefit to investigators.

Term of Contract:

Grant start date: By July 1, 2020

Additional Eligibility Criteria:

Eligible applicants:
- Applicants must have an MD, Ph.D. or MD/Ph.D. or equivalent and be appointed as faculty (or equivalent) at an academic institution.
- Applicants must have a track record of publication and funding productivity that should demonstrate that the project can be accomplished by the investigators.
- Applicant institutions may be based in the United States or abroad, and applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.

Funds may not be used for research utilizing human embryonic stem cells or non-human primates. Research with human induced pluripotent stem cells is permissible.

Pre-Application Information:

- Letter of Intent Due: October 1, 2019, by 11:59 PM
- Invitation to submit a full proposal: November 2019
- Full Application Due: January 20, 2020
- Invitation to present in person: March 2020
- Finalist Presentations: April 22, 2020
- Grant start date: By July 1, 2020

A letter of intent (LOI) must be submitted and all eligibility criteria met to be considered for the full proposal stage. The main purpose of the LOI is to determine the number of applications expected to be received.

LOIs will be reviewed administratively, and full proposals will be reviewed by an independent panel of experts according to the NIH recognized peer-review process overseen by the Crazy 8 Initiative Scientific Advisory Board.

For applicants interested in using the CCDL for gene expression analysis, please reach out to the CCDL Director, Casey Greene, PhD.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online:

For grant questions, contact:
Anna Greene, Director of Science

For technical support, contact:

Casey Greene, PhD., CCDL Director,

Alex’s Lemonade Stand Foundation
333 E. Lancaster Avenue, #414
Wynnewood, PA 19096

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon


International country outside of the USA, Israel and Canada.